BrettPhos is a promising and effective ligand in metal-catalyzed synthesis including palladium-catalyzed cross-coupling reactions, Suzuki coupling, trifluormethylation reactions and fluorinations [1-3].
A SMILES notation for BrettPhos:
C1CCCCC1P(C2CCCCC2)c3c(OC)ccc(OC)c3-c4c(C(C)C)cc(C(C)C)cc4C(C)C
References
[1] Profiles from NOS: Brett Fors: The Guy With The Namesake Ligand. Chemical & Engineering News July 11, 2011, 89 (28), page 34 [pubs.acs.org/iapps/wld/cen/results.html?line3=brett+fors&x=0&y=0].
[2] B. P. Fors, D. A. Watson, M. R. Biscoe and S. L. Buchwald: A Highly Active Catalyst for Pd-Catalyzed Amination Reactions: Cross-Coupling Reactions Using Aryl Mesylates and the Highly Selective Monoarylation of Primary Amines Using Aryl Chlorides. J. Am. Chem. Soc. October 2008, 130 (41), 13552-13554 [www.ncbi.nlm.nih.gov/pmc/articles/PMC2748321/].
[3] Patent application by S. L. Buchwald, D. A. Watson, M. Su and G. Teverovskiy: Metal-catalyzed Carbon-Fluorine Bond Formation [www.faqs.org/patents/app/20110015401].
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